MYELOID NEOPLASIA Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia

نویسندگان

  • Anna Staffas
  • Meena Kanduri
  • Randi Hovland
  • Richard Rosenquist
  • Hans Beier Ommen
  • Jonas Abrahamsson
  • Erik Forestier
  • Kirsi Jahnukainen
  • Ólafur G. Jónsson
  • Bernward Zeller
  • Josefine Palle
  • Gudmar Lönnerholm
  • Henrik Hasle
چکیده

1Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, Gothenburg, Sweden; 2Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; 3Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway; 4Laboratory of Immunohematology, Department of Hematology, Aarhus University Hospital, Aarhus, Denmark; 5Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden; 6Department of Medical Biosciences, Umeå University, Umeå, Sweden; 7Department of Pediatrics, University Central Hospital of Helsinki, Helsinki, Finland; 8Department of Pediatrics, University Hospital, Reykjavik, Iceland; 9Department of Pediatrics, Oslo University Hospital, Oslo, Norway; 10Department of Women’s and Children’s Health, University Children’s Hospital, Uppsala, Sweden; 11Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark; and 12Department of Clinical Genetics, Lund University, Lund, Sweden

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منابع مشابه

Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia.

Mutation status of FLT3, NPM1, CEBPA, and WT1 genes and gene expression levels of ERG, MN1, BAALC, FLT3, and WT1 have been identified as possible prognostic markers in acute myeloid leukemia (AML). We have performed a thorough prognostic evaluation of these genetic markers in patients with pediatric AML enrolled in the Nordic Society of Pediatric Hematology and Oncology (NOPHO) 1993 or NOPHO 20...

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Prognostic Value of BAALC Expression in Pediatric Acute Myeloid Leukemia: A Systematic Review

Background: Acute myeloid leukemia (AML) is a malignant disorder involving blood cells, characterized by obstructed or distorted differentiation of hematopoietic stem cells. In cytogenetically normal AML (CN AML), molecular abnormalities in NPM, FLT3, CEBPA, and BAALC genes are observed. Initially, high BAALC (Brain and Acute Leukemia Cytoplasmic gene) expression was introduced in a study on AM...

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BAALC expression: a suitable marker for prognostic risk stratification and detection of residual disease in cytogenetically normal acute myeloid leukemia

High brain and acute leukemia, cytoplasmic (BAALC) expression defines an important risk factor in cytogenetically normal acute myeloid leukemia (CN-AML). The prognostic value of BAALC expression in relation to other molecular prognosticators was analyzed in 326 CN-AML patients (<65 years). At diagnosis, high BAALC expression was associated with prognostically adverse mutations: FLT3 internal ta...

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High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study.

BAALC expression is considered an independent prognostic factor in cytogenetically normal acute myeloid leukemia (CN-AML), but has yet to be investigated together with multiple other established prognostic molecular markers in CN-AML. We analyzed BAALC expression in 172 primary CN-AML patients younger than 60 years of age, treated similarly on CALGB protocols. High BAALC expression was associat...

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Risk assessment in patients with acute myeloid leukemia and a normal karyotype.

PURPOSE The recognition of a number of leukemia-specific cytogenetic abnormalities and their role as independent prognostic factors have provided considerable insights into leukemia pathogenesis and have paved the way to adopt risk-adapted treatment. However, approximately 50% of newly diagnosed acute myeloid leukemia (AML) have a normal karyotype. There has therefore been much interest in iden...

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Evaluation of the CD123 Expression and FLT3 Gene Mutations in Patients with Acute Myeloid Leukemia

Background and Objective: Identification of cytogenetic and molecular changes plays an important role in acute myeloid leukemia (AML) patients. Thus, they are used in classification, prognosis and treatment of the disease. The CD123 expression and FLT3 gene mutations are also the variations that may assist in prognosis and treatment of patients with AML.Methods:</...

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تاریخ انتشار 2011