MYELOID NEOPLASIA Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia
نویسندگان
چکیده
1Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, Gothenburg, Sweden; 2Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; 3Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway; 4Laboratory of Immunohematology, Department of Hematology, Aarhus University Hospital, Aarhus, Denmark; 5Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden; 6Department of Medical Biosciences, Umeå University, Umeå, Sweden; 7Department of Pediatrics, University Central Hospital of Helsinki, Helsinki, Finland; 8Department of Pediatrics, University Hospital, Reykjavik, Iceland; 9Department of Pediatrics, Oslo University Hospital, Oslo, Norway; 10Department of Women’s and Children’s Health, University Children’s Hospital, Uppsala, Sweden; 11Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark; and 12Department of Clinical Genetics, Lund University, Lund, Sweden
منابع مشابه
Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia.
Mutation status of FLT3, NPM1, CEBPA, and WT1 genes and gene expression levels of ERG, MN1, BAALC, FLT3, and WT1 have been identified as possible prognostic markers in acute myeloid leukemia (AML). We have performed a thorough prognostic evaluation of these genetic markers in patients with pediatric AML enrolled in the Nordic Society of Pediatric Hematology and Oncology (NOPHO) 1993 or NOPHO 20...
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Background: Acute myeloid leukemia (AML) is a malignant disorder involving blood cells, characterized by obstructed or distorted differentiation of hematopoietic stem cells. In cytogenetically normal AML (CN AML), molecular abnormalities in NPM, FLT3, CEBPA, and BAALC genes are observed. Initially, high BAALC (Brain and Acute Leukemia Cytoplasmic gene) expression was introduced in a study on AM...
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High brain and acute leukemia, cytoplasmic (BAALC) expression defines an important risk factor in cytogenetically normal acute myeloid leukemia (CN-AML). The prognostic value of BAALC expression in relation to other molecular prognosticators was analyzed in 326 CN-AML patients (<65 years). At diagnosis, high BAALC expression was associated with prognostically adverse mutations: FLT3 internal ta...
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BAALC expression is considered an independent prognostic factor in cytogenetically normal acute myeloid leukemia (CN-AML), but has yet to be investigated together with multiple other established prognostic molecular markers in CN-AML. We analyzed BAALC expression in 172 primary CN-AML patients younger than 60 years of age, treated similarly on CALGB protocols. High BAALC expression was associat...
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